Cátedra de Clínica Médica – Facultad de Ciencias Médicas – Universidad Nacional de Rosario

Bibliografía:

1.       Russell James. Managment of sepsis. N Engl J Med 2006; 355:1699-1713.

2.       PROWESS Study Group. Efficacy and safety of recombinant human activated  protein C for severe sepsis. N Engl J Med 2001;344:699-709.

3.       Dellinger P. et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004; 32:858-873.

4.       ADRESS Study Group. Drotrecogin alfa for adults with severe sepsis and low risk of death. N Engl J Med 2005; 353:1332-1341.

5.       Rivers E et al. Early goal- directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345:1368-1377.

6.       Patel et al. New treatment strategies for severe sepsis and septic shock. Curr Op in Crit Care 2003; 9:390-396.

7.       Bernard GR et al. Extended evaluation of recombinant human activated protein C United States Trial. Phase 3b, Multicenter study of drotrecogin alfa in severe sepsis (ENHANCE US). Chest 2004;125:2206-2216.

8.       Ananne et al. Septic Shock. Lancet 2005; 365:63-76.

9.       Minecci et al. Meta- Analysis: The effect of steroids on survival and shock during sepsis depnds on the dose. Annals of Internal Medicine 2004; 141:47-72.

10.    Nguyen et al. Severe sepsis and septic shock: Review of the literature and Emergency Department management guidelines. Annals of Emergency Medicine 2006; 48:29-54.

11.    Gullo et al. Management of severe sepsis and septic shock: challenges and recommendations. Crit Care Clin 2006; 22:489-501.

12.    Hurtado et al. The rol of bundles in sepsis care. Crit Care Clin 2006; 22:521-529.

13.    Van der Berghe et al. Intensive insulin Therapy in the medical ICU. N Engl J Med 2006; 354:449-461.

14.    Van der Berghe et al. Intensive insulin therapy in critically ill patients. N Engl J Med 2001; 345:1359-1367.

15.    Angstwurm M et al. Selenium in Intensive Care: Results of a prospective randomized, placebo- controlled, multiple-center study in patients with severe systemic inflamatory response syndrome, sepsis and septic shock. Crit Care Med 2007; 35:118-126.