Cátedra de Clínica Médica – Facultad de Ciencias Médicas – Universidad Nacional de Rosario

Los antioxidantes son buenos… para quienes los venden, pero ¿y para los pacientes?

                Deliberadamente no hemos traducido las conclusiones para evitar errores de traducción y o interpretación.

Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis

G  Bjelakovic; D Nikolova; L Lotte Gluud ; RG Simonetti; C Gluud

JAMA. 2007;297:842-857.

LINK : http://jama.ama-assn.org/cgi/reprint/297/8/842

Conclusions: Treatment with beta carotene, vitamin A, and vitamin E may increase mortality. The potential roles of vitamin C and selenium on mortality need further study.

Más artículos relacionados:

·          Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis

EW Chong, TY Wong, AJ Kreis, JA Simpson, RH Guymer

BMJ 2007;335;755 – 13 October

http://www.bmj.com/cgi/reprint/335/7623/755

Conclusions: There is insufficient evidence to support the role of dietary antioxidants, including the use of dietary antioxidant supplements, for the primary prevention of early AMD.

·          Randomized Trials of Vitamin E in the Treatment and Prevention of Cardiovascular Disease 

RS Eidelman; D Hollar; PR Hebert; GA Lamas; CH Hennekens

Arch Intern Med. 2004;164:1552-1556.

http://archinte.ama-assn.org/cgi/reprint/164/14/1552

Conclusions: The ORs and CIs provide strong support for a lack of statistically significant or clinically important effects of vitamin E on cardiovascular disease. The use of agents of proven lack of benefit, especially those easily available over the counter, may contribute to underuse of agents of proven benefit and failure to adopt healthy lifestyles.

·          REVIEW. Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

ER. Miller; R Pastor-Barriuso; D Dalal; RA. Riemersma; LJ. Appel and E Guallar

Ann Intern Med. 2005;142:37-46 – 4 January

http://www.annals.org/cgi/reprint/142/1/37.pdf

Conclusion: High-dosage (400 IU/d) vitamin E supplements may increase all-cause mortality and should be avoided

Effects of Long-term Vitamin E Supplementation on Cardiovascular Events and Cancer A Randomized Controlled Trial

The HOPE and HOPE-TOO Trial Investigators

JAMA. 2005;293:1338-1347.  16 March

http://jama.ama-assn.org/cgi/reprint/293/11/1338

Conclusion: In patients with vascular disease or diabetes mellitus, long-term vitamin E supplementation does not prevent cancer or major cardiovascular events and may increase the risk for heart failure.